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It may be possible to grow old without developing Alzheimer’s disease pathology (ADP), although a wide range of very different types of protective factors are involved. A study published in JAMA Neurology looked at the differences in patterns of amyloid deposition and neurodegeneration that comprise ADP and found that, although challenging, “exceptional aging” without ADP is achievable.1...

Results from a systematic review and meta-analysis examining tools to detect depression in dementia show that tools incorporating collateral histories as well as a clinician interview with the patient, such as the Cornell Scale for Depression in Dementia (CSDD) or the Hamilton Depression Rating Scale (HDRS), have higher sensitivity for detecting depression, thus reducing false negatives....